G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 µM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.
Molecular Weight:
574.05
CAS Number:
[2946593-46-8]
Formula:
C31H29ClFN5O3
Target:
Others|||Ras|||Kras
T64059
* VAT and and shipping costs not included. Errors and price changes excepted