GZD856 formic is a potent, orally active inhibitor of PDGFRalpha/beta and Bcr-Abl T315I, demonstrating IC50 values of 68.6 nM and 136.6 nM for PDGFRalpha/beta, respectively, and 19.9 nM and 15.4 nM for native Bcr-Abl and the T315I mutant, respectively. This compound exhibits significant antitumor activity.
Molecular Weight:
578.58
CAS Number:
[2804039-78-7]
Formula:
C30H29F3N6O3
Target:
PDGFR|||Bcr-Abl|||Others|||Apoptosis
T64087
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