Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
Molecular Weight:
218.25
Purity:
99.55%
CAS Number:
[110117-83-4]
Formula:
C12H14N2O2
Target:
Indoleamine 2,3-Dioxygenase (IDO)|||IDO
T6543
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