Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC).
Molecular Weight:
597.49
Purity:
99.78%
CAS Number:
[357166-29-1]
Formula:
C20H33N5Na2O13
Target:
Autophagy|||DHFR|||DNA/RNA Synthesis|||Antifolate
T66032
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