BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].
Molecular Weight:
423.5
Purity:
99.46%
CAS Number:
[1909226-00-1]
Formula:
C24H29N3O4
Target:
Bcl-2 Family
T6778
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