TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
Molecular Weight:
426.45
Purity:
97.03%
CAS Number:
[2567914-01-4]
Formula:
C20H18N4O5S
Target:
Others|||NUDIX hydrolase
T67864
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