Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
Molecular Weight:
591.55
Purity:
>99.99%
CAS Number:
[1110767-45-7]
Formula:
C29H32Cl2N2O5S
Target:
p38 MAPK|||JAK|||STAT|||Thrombopoietin Receptor
T67894
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