Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.
Molecular Weight:
401.84
Purity:
97.74%
CAS Number:
[146426-40-6]
Formula:
C21H20ClNO5
Target:
Autophagy|||Apoptosis|||HIV Protease|||CDK
T6837
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