Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide, accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
Molecular Weight:
401.27
CAS Number:
[88859-04-5]
Formula:
C9H19Cl2N2O5PS2
Target:
Others
T68434
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