Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11, greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
Molecular Weight:
467.39
Purity:
97.13%
CAS Number:
[875320-31-3]
Formula:
C21H28Cl2N6O2
Target:
Autophagy|||Apoptosis|||HDAC
T6865
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