DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
Molecular Weight:
468.46
CAS Number:
[794466-17-4]
Formula:
C25H20N6O4
Target:
Others|||PLK
T68686
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