GW590735 is a potent and selective agonist of PPARalpha with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARgamma and PPARdelta. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
Molecular Weight:
500.47
CAS Number:
[343322-50-9]
Formula:
C23H20F3N2NaO4S
Target:
PPAR|||Others
T69408
* VAT and and shipping costs not included. Errors and price changes excepted
