MT477 is PKC-alpha inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.
Molecular Weight:
718.77
CAS Number:
[328069-91-6]
Formula:
C31H30N2O12S3
Target:
Others|||PKC
T69438
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