JS25 is a selective, covalent BTK inhibitor that deactivates BTK by chelating Tyr551, exhibiting an IC50 of 5.8 nM. It suppresses cancer cell proliferation, induces pronounced cell death, and enhances Burkitts lymphoma murine xenograft model outcomes. Importantly, JS25 efficiently penetrates the blood-brain barrier.
Molecular Weight:
524.59
CAS Number:
[2411771-95-2]
Formula:
C29H24N4O4S
Target:
Others|||BTK
T69646
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