BMS-986318 is a potent nonbile acid FXR agonist with EC50 values of 53 nM (FXR Gal4) and 350 nM (SRC-1 recruitment assays). It has a favorable ADME profile and demonstrates effectiveness in mouse models of liver cholestasis and fibrosis caused by bile duct ligation. BMS-986318 is used in research on nonalcoholic steatohepatitis.
Molecular Weight:
615.43
CAS Number:
[2314378-09-9]
Formula:
C30H23Cl2F3N4O3
Target:
FXR|||Others
T69686
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