MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.
Molecular Weight:
401.31
CAS Number:
[2241027-61-0]
Formula:
C20H11F4N3O2
Target:
Dehydrogenase|||Others
T69743
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