VU6007477 is a brain-penetrant and selective M1 muscarinic receptor positive allosteric modulator (PAM) with an EC50 value of 230 nM, characterized by improved central nervous system penetration compared with hydroxylated congeners, moderate permeability as a human P-glycoprotein substrate, a pyranyl amide chemical scaffold, and strong suitability for experimental investigations into robust cholinergic seizure activity, central cholinergic signaling, and neurological disease models requiring reliable CNS exposure.
Molecular Weight:
430.5
Purity:
99.67%
CAS Number:
[2220141-46-6]
Formula:
C24H26N6O2
Target:
AChR
T69780
T69780
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