BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor alpha (RXRalpha) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
Molecular Weight:
413.39
CAS Number:
[2095489-35-1]
Formula:
C22H18F3N3O2
Target:
Others|||NR4A|||Retinoid Receptor
T69921
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