INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes, inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes.
Molecular Weight:
730.932
CAS Number:
[2081940-67-0]
Formula:
C37H50N2O9S2
Target:
Histone Demethylase|||Others
T69937
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