APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes oncogenic Ras-MAPK signaling.
Molecular Weight:
387.43
CAS Number:
[2002381-25-9]
Formula:
C23H21N3O3
Target:
Others|||MEK
T70004
* VAT and and shipping costs not included. Errors and price changes excepted