NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
Molecular Weight:
650.74
CAS Number:
[1964516-64-0]
Formula:
C31H24F2N4O4S3
Target:
Others|||ROS|||Apoptosis|||Dehydrogenase
T70032
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