L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
Molecular Weight:
478.802
CAS Number:
[183499-56-1]
Formula:
C22H22Cl3N5O
Target:
Others|||Transferase
T70134
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