BMS-37 is a PD-1/PD-L1 immune checkpoint inhibitor exhibiting IC50 values ranging from 18 to 200 nM against the PD-L1/PD-1 complex, while displaying nonspecific cytotoxicity toward modified Jurkat T cells with EC50 values between 3 and 6 µM, and it is widely used to investigate PD-L1-induced T-cell exhaustion mechanisms or as a PD-L1 ligand scaffold for the rational design and synthesis of PROTAC molecules in immuno-oncology research.
Molecular Weight:
448.55
CAS Number:
[1675202-20-6]
Formula:
C27H32N2O4
Target:
PD-1/PD-L1
T70286
T70286
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