Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).
Molecular Weight:
461.93
CAS Number:
[1609392-28-0]
Formula:
C20H20D3ClN8O3
Target:
JAK|||IFNAR|||Interleukin
T70394
* VAT and and shipping costs not included. Errors and price changes excepted
