VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H4 receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and beta-arrestin2 recruitment. VUF14480 bound covalently to the hH4 receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.
Molecular Weight:
280.37
CAS Number:
[1605304-31-1]
Formula:
C17H20N4
Target:
Others
T70403
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