Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of ciprokinen lead to a reduction in arterial blood pressure. Development of ciprokinen was discontinued at a preclinical stage.
Molecular Weight:
729.93
CAS Number:
[143631-62-3]
Formula:
C37H55N5O8S
Target:
Others|||RAAS
T70654
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