GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especially those who have acquired resistance to ibrutinib by mutation of Cys481 or Thr474.
Molecular Weight:
564.64
CAS Number:
[1433820-83-7]
Formula:
C30H32N10O2
Target:
Others|||BTK
T70668
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