Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Abeta40, Abeta42, and sAbetaPPbeta.
Molecular Weight:
448.995
CAS Number:
[1383986-31-9]
Formula:
C26H29ClN4O
Target:
Others|||Beta-Secretase
T70807
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