Banoxantrone (AQ4N), a hypoxia-selective cytotoxin prototype, undergoes reduction to AQ4, effectively inhibiting topoisomerase II. It selectively targets and eradicates hypoxic cells through an iNOS-dependent mechanism. This compound demonstrates significant cytotoxicity with its hypoxia-selective action being augmented by radiation.
Molecular Weight:
444.48
CAS Number:
[136470-65-0]
Formula:
C22H28N4O6
Target:
Others|||NO Synthase
T70860
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