HM90822 is a novel synthetic apoptotic protein (IAP) antagonist that induces apoptosis in human pancreatic cancer cells through proteasome-dependent degradation of IAPs containing the BIR2/3 structural domain.HM90822 inhibits the expression of XIAP and cIAP1/2 proteins in HM822-sensitive Panc-1 and BxPC-3 cells, induces ubiquitylation of IAPs and promotes induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.
Molecular Weight:
632.1
Purity:
99.66%
CAS Number:
[1363145-46-3]
Formula:
C30H36ClF2N7O4
Target:
Apoptosis|||IAP
T70868
* VAT and and shipping costs not included. Errors and price changes excepted