Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the alpha4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyers patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.
Molecular Weight:
548.801
CAS Number:
[1338380-52-1]
Formula:
C25H20Cl3N3O5
Target:
Others|||Integrin
T70944
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