PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-kappaB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
Molecular Weight:
312.28
CAS Number:
[1246668-32-5]
Formula:
C16H12N2O5
Target:
Others
T71147
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