Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpins folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
Molecular Weight:
294.31
CAS Number:
[1225177-95-6]
Formula:
C16H14N4O2
Target:
Others|||SARS-CoV
T71191
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