ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11beta-HSD1. The effects of ASP3662 suggest that selective inhibition of 11beta-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia. ASP3662 inhibited human, mouse and rat 11beta-HSD1 but not human 11beta-HSD2, in vitro. ASP3662 inhibited in vitro conversion of glucocorticoid from its inactive to active form in extracts of rat brain and spinal cord.
Molecular Weight:
424.8
CAS Number:
[1204178-50-6]
Formula:
C19H16ClF3N4O2
Target:
Others|||Dehydrogenase
T71243
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