Lobaric acid is a depsidone metabolite isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activities. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 µmol), inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 µg/ml), inhibits protein tyrosine phosphatase 1B (PTP1B, IC50 = 0.87 µM for the human recombinant enzyme), and inhibits production of 12(S)-HETE [Item No. 34570] by 12(S)-lipoxygenase (IC50 = 28.5 µM). In vivo, lobaric acid (250 µM) reduces lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).
Molecular Weight:
456.48
CAS Number:
[522-53-2]
Formula:
C25H28O8
Target:
Others|||TMV|||Lipoxygenase|||Phosphatase
T71811
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