(rac)-AG-205 serves as a robust inhibitor of the progesterone receptor membrane component 1 (Pgrmc1), crucial for inducing genes linked to sterol synthesis, notably the INSIG1 protein, which interacts with PGRMC1. Additionally, it plays a pivotal role in mitigating neuronal resistance to hypoxic ischaemia by inhibiting NF-kB signalling and the activation of the BDNF/PI3K/AKT pathway.
Molecular Weight:
454.98
CAS Number:
[442656-02-2]
Formula:
C22H23ClN6OS
Target:
Others|||NF-kappaB|||Akt
T71827
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