Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 is effective in inducing autophagy in vitro and can be used for prevention and human treatment of acute liver injury (ALI).
Molecular Weight:
430.48
Purity:
99.79%
CAS Number:
[2922550-28-3]
Formula:
C24H23FN6O
Target:
CDK|||Autophagy|||DYRK
T72039
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