1-Dehydro-[10]-gingerdione inhibits IKKbeta activity by targeting its activation loop, thereby preventing IKKbeta-mediated phosphorylation of IkappaBalpha in macrophages stimulated by agonists. Furthermore, this compound suppresses LPS-induced NF-kappaB transcriptional activity, highlighting its potential in research related to NF-kappaB-associated inflammation and autoimmune disorders [1].
Molecular Weight:
346.46
CAS Number:
[136826-50-1]
Formula:
C21H30O4
Target:
IkappaB/IKK|||NF-kappaB|||Others
T72208
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