Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC).
Molecular Weight:
434.94
Purity:
98.81%
CAS Number:
[2222138-31-8]
Formula:
C20H23ClN4O3S
Target:
CSF-1R|||c-Fms
T72211
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