PBT434 methanesulfonate is an orally active, potent alpha-synuclein aggregation inhibitor with the ability to cross the blood-brain barrier. Acting as an iron chelator, it modulates transcellular iron trafficking, inhibits iron-mediated redox activity, and prevents iron-mediated aggregation of alpha-synuclein. PBT434 methanesulfonate also safeguards against the loss of substantia nigra pars compacta neurons (SNpc), showing promise for Parkinsons disease (PD) research.
Molecular Weight:
398.26
CAS Number:
[2387898-69-1]
Formula:
C13H17Cl2N3O5S
Target:
Others
T72280
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