Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kdelta and casein kinase-1-epsilon (CK1epsilon), with EC50 values of 22.2 nM and 6.0 µM, respectively. It demonstrates unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) and is applicable in the research of hematological malignancies.
Molecular Weight:
669.63
CAS Number:
[1532533-75-7]
Formula:
C31H26F3N5O7S
Target:
PI3K|||Casein Kinase|||Others
T72527
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