VEGFR-2/BRAF-IN-1, a dual inhibitor of VEGFR-2 and BRAF kinases, demonstrates potent inhibitory activity with IC50 values of 0.049 µM for VEGFR-2, 0.063 µM for BRAF V600E, and 0.005 µM for BRAF WT. It effectively induces apoptosis and arrests the cell cycle primarily at the G1/S phase.
Molecular Weight:
642.5
Formula:
C26H20Cl2F3N5O3S2
Target:
Apoptosis|||Raf|||VEGFR|||Others
T72607
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