cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.
Molecular Weight:
446.9
Purity:
99.75%
CAS Number:
[2361988-77-2]
Formula:
C26H20ClFN2O2
Target:
Caspase|||Apoptosis|||RIP kinase
T72658
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