KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 µM for KRAS WT, 0.63 µM for KRAS G12C, 0.37 µM for KRAS G12D, and 0.74 µM for KRAS Q61H). Additionally, it impedes the interaction between KRAS and Raf, highlighting its potential as a targeted therapeutic agent in KRAS-mutant cancers.
Molecular Weight:
413.51
CAS Number:
[900897-56-5]
Formula:
C25H27N5O
Target:
Others|||Kras|||Ras
T72659
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