Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-alpha). By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].
Molecular Weight:
765.9
CAS Number:
[2796292-75-4]
Formula:
C36H43N7O8S2
Target:
Nrf2|||Others|||NO Synthase|||ROS Kinase
T72687
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