UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 µM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 µM and 16 µM, respectively.
Molecular Weight:
474.31
CAS Number:
[2376687-49-7]
Formula:
C19H13BrFN5O2S
Target:
DNA/RNA Synthesis|||Others
T72696
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