AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 µM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 7.16 µM. It demonstrates significant hydroxyl radical (OH) scavenging activity, achieving an IC50 of 0.1674 µM, and effectively inhibits reactive oxygen species (ROS) and Abeta 1-42 aggregation, including self-aggregation, copper (Cu 2+)-induced, and AChE-induced aggregation. Characterized by high blood-brain barrier (BBB) permeability, bioavailability, and low cellular toxicity, AChE/BuChE-IN-1 holds promising potential for Alzheimers disease (AD) research.
Molecular Weight:
325.36
CAS Number:
[84212-49-7]
Formula:
C19H19NO4
Target:
Cholinesterase (ChE)|||Others
T72763
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