CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor suppressor protein (Rb) at S780, as well as suppressing E2 factor (E2F)-regulated gene expression.
Molecular Weight:
442.56
CAS Number:
[2078047-99-9]
Formula:
C21H27FN8S
Target:
CDK|||Others
T72928
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