Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.
Molecular Weight:
360.44
Purity:
95.54%
CAS Number:
[1011528-58-7]
Formula:
C21H28O5
Target:
SIK
T73074
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