Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that specifically inhibits the reduced folate carrier (RFC), selectively impeding RFC transport and targeting dihydrofolate reductase (DHFR) to demonstrate antitumor activity and inhibit tumor growth [1] [2].
Molecular Weight:
573.56
CAS Number:
[113857-87-7]
Formula:
C27H27N9O6
Target:
DHFR|||Others|||Antifolate
T73085
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